Pyridostigmine-induced high grade SA-block in a patient with myasthenia gravis
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چکیده
منابع مشابه
Pyridostigmine-induced high grade SA-block in a patient with myasthenia gravis
PATIENT Female, 70 FINAL DIAGNOSIS: SA block induced by pyridostigmine Symptoms: Asymptomatic Medication: Pyridostigmine Clinical Procedure: Pacemaker insertion Specialty: Electrophysiology. OBJECTIVE Unusual clinical course. BACKGROUND Myasthenia gravis requires a long-term treatment with a parasympathomimetic agent, which may result in bradycardia and asystole. Pharmacologic treatment wit...
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Reversible acetylcholinesterase inhibitors are used as first-line treatment for myasthenia gravis. They improve symptoms by increasing concentration of acetylcholine at the neuromuscular junction and stimulating nicotinic receptors. Serious bradyarrhythmias can occur from muscarinic stimulation in heart, which in rare cases may progress to asystole. These patients can initially be managed with ...
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The decrease of “functional” endplate receptors in MG can decrease the response to the chemical transmitter acetylcholine, as well as to the depolarizing muscle relaxant succinylcholine. In contrast, the decreased “safety margin” results in a marked sensitivity to nondepolarising relaxants. In normal patients, the wide “safety margin” may explain the slow onset of nondepolarizing block, as well...
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ژورنال
عنوان ژورنال: American Journal of Case Reports
سال: 2013
ISSN: 1941-5923
DOI: 10.12659/ajcr.889484